Invention Grant
- Patent Title: Bicyclic thiazoles as allosteric modulators of mGluR5 receptors
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Application No.: US13516985Application Date: 2010-12-16
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Publication No.: US09040707B2Publication Date: 2015-05-26
- Inventor: Gregor James MacDonald , Andrés Avelino Trabanco-Suárez , Susana Conde-Ceide , Gary John Tresadern , José Manuel Bartolomé-Nebreda , Joaquin Pastor-Fernández
- Applicant: Gregor James MacDonald , Andrés Avelino Trabanco-Suárez , Susana Conde-Ceide , Gary John Tresadern , José Manuel Bartolomé-Nebreda , Joaquin Pastor-Fernández
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agent Hal B. Woodrow
- Priority: EP09179850 20091218; EP10193019 20101129
- International Application: PCT/EP2010/069957 WO 20101216
- International Announcement: WO2011/073339 WO 20110623
- Main IPC: A61K31/4365
- IPC: A61K31/4365 ; C07D513/04
Abstract:
The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.
Public/Granted literature
- US20120258955A1 BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS Public/Granted day:2012-10-11
Information query
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