Invention Grant
- Patent Title: Genetically modified major histocompatibility complex animals
- Patent Title (中): 转基因主要组织相容性复合动物
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Application No.: US13793935Application Date: 2013-03-11
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Publication No.: US09043996B2Publication Date: 2015-06-02
- Inventor: Lynn MacDonald , Andrew J. Murphy , Naxin Tu , Cagan Gurer , Vera Voronina , Sean Stevens
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Brownstein Hyatt Farber Schreck, LLP
- Agent Rita S. Wu; Margarita Zippin
- Main IPC: A01K67/027
- IPC: A01K67/027 ; A61K39/00 ; C07H21/04 ; C07K14/74
Abstract:
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the humanized MHC II protein. Also provided are constructs for and methods of making the genetically modified non-human animals. Methods of using the genetically modified non-human animals to study various aspects of the human immune system are provided.
Public/Granted literature
- US20130185820A1 Genetically Modified Major Histocompatibility Complex Animals Public/Granted day:2013-07-18
Information query
