Patient support systems are generally disclosed. An example patient support system may be configured to provide a predictive bed-exit alarm and/or a patient weight. An example embodiment may include a support structure including independently inflatable supports, an inflatable mat beneath the inflatable supports, and pressure detectors associated with the inflatable supports and the inflatable mat. An alarm logic may be configured to initiate a predictive bed-exit alarm sequence upon determining that at least one of the pressures of the inflatable supports is at about its respective unloaded pressure. A patient weight logic may be configured to output a patient weight based at least partially upon a difference between an unloaded pressure and a loaded pressure of the inflatable mat.