A pharmaceutical waste disposal assembly (10) for disposing of raw pharmaceutical waste comprises a first receiver body (19) and a first reaction agent (287). The first receiver body (19) receives the pharmaceutical waste. The first receiver body (19) includes a receiver bottom (283). The first reaction agent (287) is positioned within the first receiver body (19) and spaced apart from the receiver bottom (283). The pharmaceutical waste reacts with the first reaction agent (287) to change the pharmaceutical waste in one of a chemical and physical manner so that the pharmaceutical waste is unrecoverable. The first receiver body (19) can receive fluid pharmaceutical waste and/or solid pharmaceutical waste. The first reaction agent (287) may include one or more of a denaturant, an emetic and a tittering agent. For example, the first reaction agent (287) may include one or more of quinine, ipecac and denatonium benzoate.