Invention Grant
US09044424B2 Methods of regulating glucose metabolism, and reagents related thereto
有权
调节葡萄糖代谢的方法及与其相关的试剂
- Patent Title: Methods of regulating glucose metabolism, and reagents related thereto
- Patent Title (中): 调节葡萄糖代谢的方法及与其相关的试剂
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Application No.: US13951060Application Date: 2013-07-25
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Publication No.: US09044424B2Publication Date: 2015-06-02
- Inventor: William W. Bachovchin , Andrew G. Plaut , Daniel J. Drucker
- Applicant: Trustees of Tufts College , New England Medical Center Hospitals, Inc. , 1149336 Ontario, Inc.
- Applicant Address: CA Toronto, Ontario US MA Boston US MA Boston
- Assignee: 1149336 Ontario, Inc.,New England Medical Center Hospitals. Inc.,Trustees of Tufts College
- Current Assignee: 1149336 Ontario, Inc.,New England Medical Center Hospitals. Inc.,Trustees of Tufts College
- Current Assignee Address: CA Toronto, Ontario US MA Boston US MA Boston
- Agency: Foley Hoag LLP
- Agent Dana M. Gordon
- Main IPC: A61K38/02
- IPC: A61K38/02 ; A61K38/05 ; A61K38/55 ; A61K31/00 ; A61K31/155 ; A61K31/401 ; A61K31/4025 ; A61K31/675 ; A61K31/69 ; A61K31/702 ; A61K45/06
Abstract:
The present invention provides methods for modification and regulation of glucose metabolism by administering to an animal a therapeutically effective amount of an inhibitor of dipeptidylpeptidase IV (DPIV) or a pharmaceutically acceptable salt thereof, where the inhibitor has a Ki for inhibition of DPIV of 10 nM or less; and the inhibitor is administered in an amount sufficient to increase the plasma half-life of glucagon-like peptide 1 (GLP-1) but not sufficient to suppress the immune system of the animal.
Public/Granted literature
- US20140178472A1 Methods of Regulating Glucose Metabolism, and Reagents Related Thereto Public/Granted day:2014-06-26
Information query
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