Invention Grant
US09044445B2 Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens
有权
马赛克进化枝M人类免疫缺陷病毒1型（HIV-1）gag免疫原
- Patent Title: Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens
- Patent Title (中): 马赛克进化枝M人类免疫缺陷病毒1型（HIV-1）gag免疫原
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Application No.: US12737761Application Date: 2009-08-14
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Publication No.: US09044445B2Publication Date: 2015-06-02
- Inventor: Bette T. Korber , William Fischer , Norman Letvin , Hua-Xin Liao , Barton F. Haynes , Beatrice H. Hahn
- Applicant: Bette T. Korber , William Fischer , Norman Letvin , Hua-Xin Liao , Barton F. Haynes , Beatrice H. Hahn
- Applicant Address: US NM Los Alamos US MA Boston US NC Durham US AL Birmingham
- Assignee: LOS ALAMOS NATIONAL SECURITY, LLC,BETH ISRAEL DEACONESS MEDICAL CENTER,DUKE UNIERSITY,THE UAB RESEARCH FOUNDATION
- Current Assignee: LOS ALAMOS NATIONAL SECURITY, LLC,BETH ISRAEL DEACONESS MEDICAL CENTER,DUKE UNIERSITY,THE UAB RESEARCH FOUNDATION
- Current Assignee Address: US NM Los Alamos US MA Boston US NC Durham US AL Birmingham
- Agency: Nixon & Vanderhye P.C.
- International Application: PCT/US2009/004664 WO 20090814
- International Announcement: WO2010/019262 WO 20100218
- Main IPC: A61K39/21
- IPC: A61K39/21 ; C07K14/005 ; A61K39/00
Abstract:
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine containing nucleic acids encoding HIV-1 gag mosaic proteins, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
Public/Granted literature
- US20120121631A1 POLYVALENT VACCINE Public/Granted day:2012-05-17
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