Invention Grant
- Patent Title: Antigenic peptide of HSV-2 and methods for using same
- Patent Title (中): HSV-2的抗原肽及其使用方法
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Application No.: US13262833Application Date: 2010-04-03
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Publication No.: US09044447B2Publication Date: 2015-06-02
- Inventor: Lawrence Corey , Kerry J. Laing , Anna Wald , David M. Koelle
- Applicant: Lawrence Corey , Kerry J. Laing , Anna Wald , David M. Koelle
- Applicant Address: US WA Seattle US WA Seattle
- Assignee: UNIVERSITY OF WASHINGTON,FRED HUTCHISON CANCER RESEARCH CENTER
- Current Assignee: UNIVERSITY OF WASHINGTON,FRED HUTCHISON CANCER RESEARCH CENTER
- Current Assignee Address: US WA Seattle US WA Seattle
- Agency: canady + lortz LLP
- Agent Karen S. Canady
- International Application: PCT/US2010/029880 WO 20100403
- International Announcement: WO2010/115172 WO 20101007
- Main IPC: A61K39/245
- IPC: A61K39/245 ; A61K9/19 ; C07K14/005 ; A61K39/00 ; C07K7/08 ; A61K9/00
Abstract:
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection, including epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.
Public/Granted literature
- US20120027789A1 ANTIGENIC PEPTIDE OF HSV-2 AND METHODS FOR USING SAME Public/Granted day:2012-02-02
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