Invention Grant
US09044494B2 Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21
有权
通过抑制FGF21的天然反义转录物来治疗成纤维细胞生长因子21（FGF21）相关疾病
- Patent Title: Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21
- Patent Title (中): 通过抑制FGF21的天然反义转录物来治疗成纤维细胞生长因子21（FGF21）相关疾病
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Application No.: US13638967Application Date: 2011-04-08
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Publication No.: US09044494B2Publication Date: 2015-06-02
- Inventor: Joseph Collard , Olga Khorkova Sherman
- Applicant: Joseph Collard , Olga Khorkova Sherman
- Applicant Address: US FL Miami
- Assignee: CuRNA, Inc.
- Current Assignee: CuRNA, Inc.
- Current Assignee Address: US FL Miami
- Agency: CuRNA, Inc.
- Agent Monte R. Browder
- International Application: PCT/US2011/031665 WO 20110408
- International Announcement: WO2011/127337 WO 20111013
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/7088
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Fibroblast growth factor 21 (FGF21), in particular, by targeting natural antisense polynucleotides of Fibroblast growth factor 21 (FGF21). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of FGF21.
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