Invention Grant
- Patent Title: Amino alcohol cationic lipids for oligonucleotide delivery
- Patent Title (中): 用于寡核苷酸递送的氨基醇阳离子脂质
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Application No.: US14325951Application Date: 2014-07-08
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Publication No.: US09044512B2Publication Date: 2015-06-02
- Inventor: Brian W. Budzik , Steven L. Colletti , Darla Danile Seifried , Matthew G. Stanton , Lu Tian
- Applicant: Sirna Therapeutics, Inc.
- Applicant Address: US MA Cambridge
- Assignee: SIRNA THERAPEUTICS, INC.
- Current Assignee: SIRNA THERAPEUTICS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Nixon Peabody LLP
- Main IPC: A61K47/18
- IPC: A61K47/18 ; A61K31/713 ; C07C217/40 ; C07C217/28 ; C12N15/87 ; C07D263/14
Abstract:
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is more efficacious than traditional cationic lipids. The present invention employs amino alcohols to enhance the efficiency of in vivo delivery of siRNA.
Public/Granted literature
- US20140323548A1 NOVEL AMINO ALCOHOL CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY Public/Granted day:2014-10-30
Information query
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