Invention Grant
- Patent Title: Lipid-peptide-polymer conjugates and nanoparticles thereof
- Patent Title (中): 脂质 - 肽 - 聚合物缀合物及其纳米颗粒
-
Application No.: US13610637Application Date: 2012-09-11
-
Publication No.: US09044514B2Publication Date: 2015-06-02
- Inventor: Ting Xu , He Dong , Jessica Shu
- Applicant: Ting Xu , He Dong , Jessica Shu
- Applicant Address: US CA Oakland
- Assignee: REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee: REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: A61K47/42
- IPC: A61K47/42 ; A61K47/48 ; B82Y5/00
Abstract:
The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.
Public/Granted literature
- US20130121917A1 Lipid-Peptide-Polymer Conjugates and Nanoparticles Thereof Public/Granted day:2013-05-16
Information query
IPC分类:
