A filtration system is disclosed comprising a filter manifold and a filter cartridge. The filter manifold comprises a bracket, a valve, a manifold feed port, a manifold filtrate port, and a handle. The valve is held by the bracket and comprises a fixed portion attached to the bracket and a rotary portion. The handle is operatively connected to the rotary portion and comprises a cartridge lifter having one of a camming ramp or a camming lug lifter engagement feature. The handle is rotatable to a service position and a disengaged position, wherein the manifold feed port is blocked by the valve when the handle is in the disengaged position. The filter cartridge comprises a cartridge feed port, a cartridge filtrate port, and an external cartridge surface having one of a camming lug or a camming ramp for engaging the lifter engagement feature.