Invention Grant
US09045425B2 Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
有权
固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺
![Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/docs/US/2015-06-02/US09045425B2/abs.jpg.600x600.jpg)
- Patent Title: Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
- Patent Title (中): 固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺
-
Application No.: US14163396Application Date: 2014-01-24
-
Publication No.: US09045425B2Publication Date: 2015-06-02
- Inventor: Brian Luisi , Sneha Ghanshyam Arekar , Adriana Costache , Kirk Raymond Dinehart , Steven C. Johnston , Bobbianna J. Neubert-Langille
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Christopher C. Forbes; Jonathan P. O'Brien
- Main IPC: C07D215/56
- IPC: C07D215/56 ; A61K31/47 ; A61K45/06
![Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide](/abs-image/US/2015/06/02/US09045425B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to crystalline solvate forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods for their preparation. The present invention further relates to pharmaceutical compositions comprising the crystalline solvate forms, as well as methods of treatment therewith.
Public/Granted literature
- US20140142312A1 SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE Public/Granted day:2014-05-22
Information query
