Invention Grant
- Patent Title: Nitric oxide donor neprilysin inhibitors
- Patent Title (中): 一氧化氮供体neprilysin抑制剂
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Application No.: US13905338Application Date: 2013-05-30
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Publication No.: US09045443B2Publication Date: 2015-06-02
- Inventor: Mathai Mammen , Adam D. Hughes
- Applicant: Mathai Mammen , Adam D. Hughes
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah
- Main IPC: C07D261/18
- IPC: C07D261/18 ; C07D413/12 ; C07D271/08 ; C07C235/80 ; A61K31/42 ; A61K31/4245 ; A61K31/216 ; C07C233/56 ; A61K45/06 ; C07D271/04 ; C07C243/28
Abstract:
In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R7, R8, Z, X, b, and c are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are nitric oxide donors and have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Public/Granted literature
- US20130323271A1 NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS Public/Granted day:2013-12-05
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