Invention Grant
US09045527B2 Small molecule conjugates with dimetal species for protein inhibition
有权
小分子偶联物与二重物质进行蛋白质抑制
- Patent Title: Small molecule conjugates with dimetal species for protein inhibition
- Patent Title (中): 小分子偶联物与二重物质进行蛋白质抑制
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Application No.: US13916359Application Date: 2013-06-12
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Publication No.: US09045527B2Publication Date: 2015-06-02
- Inventor: Zachary T. Ball , Rituparna Kundu , Brian V. Popp , Dean R. Madden , Patrick R. Cushing
- Applicant: WILLIAM MARSH RICE UNIVERSITY
- Applicant Address: US TX Houston US NH Hanover
- Assignee: WILLIAM MARSH RICE UNIVERSITY,TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee: WILLIAM MARSH RICE UNIVERSITY,TRUSTEES OF DARTMOUTH COLLEGE
- Current Assignee Address: US TX Houston US NH Hanover
- Agency: Reed Smith LLP
- Agent Robert R. Riddle
- Main IPC: C07K7/00
- IPC: C07K7/00 ; C07K14/435 ; C07H21/00 ; C07K1/107 ; A61K47/48
Abstract:
Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to interact. The rhodium(II) complex covalently linked to the inhibitor binds the target protein both inorganically and organically and forms stabilizing secondary contacts between the rhodium(II) complex and the protein.
Public/Granted literature
- US20140011983A1 SMALL MOLECULE CONJUGATES WITH DIMETAL SPECIES FOR PROTEIN INHIBITION Public/Granted day:2014-01-09
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