Invention Grant
- Patent Title: huTNFR1 selective antagonists
- Patent Title (中): huTNFR1选择性拮抗剂
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Application No.: US13765923Application Date: 2013-02-13
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Publication No.: US09045535B2Publication Date: 2015-06-02
- Inventor: Klaus Pfizenmaier , Peter Scheurich , Roland Kontermann , Sabine Muenkel
- Applicant: UNIVERSITAET STUTTGART
- Applicant Address: DE
- Assignee: Universitaet Stuttgart
- Current Assignee: Universitaet Stuttgart
- Current Assignee Address: DE
- Agency: Perkins Coie LLP
- Priority: EP07005603 20070319
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C07K16/28 ; C07K16/24 ; A61K38/00
Abstract:
The present invention relates to a ligand, which specifically binds to human tumor necrosis factor type 1 receptor (huTNFR1). The ligand includes one or more amino acid sequences of human origin capable of reducing the immunogenic response of the ligand in humans and one or more amino acid sequences capable of selectively binding to huTNFR1. The present invention also relates to a nucleic acid sequence encoding the ligand and to a pharmaceutical composition for the treatment of disorders related to huTNFR1.
Public/Granted literature
- US20130244341A1 huTNFR1 SELECTIVE ANTAGONISTS Public/Granted day:2013-09-19
Information query
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