Invention Grant
- Patent Title: Compositions and methods for modulating lymphocyte activity
- Patent Title (中): 用于调节淋巴细胞活性的组合物和方法
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Application No.: US13341611Application Date: 2011-12-30
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Publication No.: US09045562B2Publication Date: 2015-06-02
- Inventor: Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
- Applicant: Kenneth M. Murphy , Theresa L. Murphy , John R. Sedy , Michelle A. Hurchla Pyles , Norihiko Watanabe , Jianfei Yang
- Applicant Address: US MO St. Louis
- Assignee: Washington University
- Current Assignee: Washington University
- Current Assignee Address: US MO St. Louis
- Agency: Polsinelli PC
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/705 ; A61K39/00
Abstract:
The present invention provides a novel lymphocyte inhibitory receptor termed BTLA which is expressed on both T and B cells, and identifies HVEM as interacting with BTLA. Methods and compositions for modulating BTLA-mediated signaling and interfering with the interaction of BTLA and HVEM for therapeutic, diagnostic and research purposes are also provided.
Public/Granted literature
- US20120207759A1 COMPOSITIONS AND METHODS FOR MODULATING LYMPHOCYTE ACTIVITY Public/Granted day:2012-08-16
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