Invention Grant
- Patent Title: NKX3-1 saRNA and KLF4 saRNA and uses thereof
- Patent Title (中): NKX3-1 saRNA和KLF4 saRNA及其用途
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Application No.: US13583905Application Date: 2011-03-08
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Publication No.: US09045752B2Publication Date: 2015-06-02
- Inventor: Long-Cheng Li
- Applicant: Long-Cheng Li
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Edward J. Baba; Shweta Chandra
- International Application: PCT/US2011/027587 WO 20110308
- International Announcement: WO2011/112607 WO 20110915
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04 ; C07H21/02 ; C12N15/113 ; A61K31/7105 ; C12N15/67 ; C12Q1/68
Abstract:
The present disclosure provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a NKX3-1 gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a promoter region sequence of the NKX3-1 gene. The present disclosure also provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a KLF4 gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a promoter region sequence of the KLF4 gene.
Public/Granted literature
- US20130096184A1 NKX3-1 SARNA AND KLF4 SARNA AND USES THEREOF Public/Granted day:2013-04-18
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