Invention Grant
- Patent Title: Linear donor constructs for targeted integration
- Patent Title (中): 用于靶向整合的线性供体构建体
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Application No.: US13134766Application Date: 2011-06-16
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Publication No.: US09045763B2Publication Date: 2015-06-02
- Inventor: Russell DeKelver , Philip D. Gregory , Michael C. Holmes , Fyodor Urnov
- Applicant: Russell DeKelver , Philip D. Gregory , Michael C. Holmes , Fyodor Urnov
- Applicant Address: US CA Richmond
- Assignee: Sangamo BioSciences, Inc.
- Current Assignee: Sangamo BioSciences, Inc.
- Current Assignee Address: US CA Richmond
- Agency: Pasternak Patent Law
- Agent Susan Abrahamson
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C12N15/00 ; C12N15/87 ; C12N15/82 ; C12N15/90
Abstract:
Disclosed herein are linear donor molecules comprising homology arms of 50-750 base pairs (e.g., 50-100 base pairs) flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for integration of an exogenous sequence into a specified region of interest in the genome of a cell.
Public/Granted literature
- US20110281361A1 Linear donor constructs for targeted integration Public/Granted day:2011-11-17
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