An adjustable mudline suspension system, including a tubing hanger having an exterior profile, a clamp having an inner profile to mate with the exterior profile of the tubing hanger, a biasing element to bias the clamp radially inward into an engaged position where the inner and exterior profiles are mated, and a piston to bias the clamp radially outward into a disengaged position where the inner and exterior profiles are not mated when hydraulically actuated. The weight of the tubing hanger is supported by the adjustable mudline suspension system when the interior profile of the clamp mates with the exterior profile of the hanger.