Invention Grant
- Patent Title: Dynamic MR imaging of patients with breast cancer—establishment and comparison of different analytical methods for tissue perfusion and capillary permeability
- Patent Title (中): 乳腺癌患者的动态MR成像建立和不同分析方法对组织灌注和毛细血管通透性的比较
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Application No.: US14068734Application Date: 2013-10-31
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Publication No.: US09046589B2Publication Date: 2015-06-02
- Inventor: Kjell-Inge Gjesdal , Endre Grøvik
- Applicant: Kjell-Inge Gjesdal , Endre Grøvik
- Applicant Address: NO Alesund
- Assignee: SUNNMORE MR-KLINIKK AS
- Current Assignee: SUNNMORE MR-KLINIKK AS
- Current Assignee Address: NO Alesund
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
- Priority: NO201011638 20101122
- Main IPC: G06K9/00
- IPC: G06K9/00 ; G01R33/56 ; A61B5/055 ; A61B5/00 ; G01R33/563 ; G01R33/28 ; G01R33/48

Abstract:
The present invention encompasses methods, apparatus, and computer based systems for identifying benign and malignant tumors in tissues such as soft tissues and particularly breast tissue using dynamic contrast-enhanced magnetic resonance imagining (DCE-MRI) and dynamic susceptibility contrast-enhanced magnetic resonance (DSC) imagining of the tumors. Some embodiments encompass the use of two dynamic MRI pulse sequences in intercalating mode during parenteral administration of an MR contrast substance, wherein one of said pulse sequences is optimized for spatial information and the other pulse sequence is adjusted for high temporal solution, the high-temporal dissolved sequence further comprising a double echo-collection sensitive towards both DCE and DSC for generating a number of different biomarker data such as pharmacokinetic biomarker data, descriptive DCE biomarkers and descriptive DSC biomarkers, and subsequently normalizing and comparing said data with corresponding data from corresponding benign and malign tumors, respectively.
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