A calibration method and apparatus for current and resistance are provided, where the current calibration method includes: injecting at least one portion of a set of predetermined compensation currents into at least one of an output current of a first current source and an output current of a second current source, and dynamically adjusting a distribution of the at least one portion of the set of predetermined compensation currents until two monitored voltage drops are equal to each other, and recording a first compensation current configuration; exchanging the first and second current sources, and dynamically adjusting the distribution of the at least one portion of the set of predetermined compensation currents until the two monitored voltage drops are equal to each other, and recording a second compensation current configuration; and according to the first and second compensation current configurations, generating a resultant compensation current, for use of current compensation.