A parameter relating to the video card preferences of a target computer program is determined. In response to the target computer program being started on a computing device having a number of video cards, one of these video cards is selected to run the target computer program on, based on the parameter. The target computer program is then run on the video card selected. The parameter may include the specific identify of one of the video cards on which the target computer program is to be run, as well as other types of parameters that do not specifically identify any of the video cards. The video card preferences of the target computer program may also include video card requirements of the target computer program.