Systems, methods, and devices for performing column inversion using 2-column demultiplexers are provided. In one example, an electronic display may include a display panel with columns of pixels configured to be programmed with frames of image data and display driver circuitry. The display driver circuitry may include three demultiplexers, each respectively coupled to one pixel column of a first superpixel and one pixel column of a second superpixel. Each of the three demultiplexers may receive amplified image data of a single polarity per frame.