One embodiment of the disclosure provides an electrostatic discharge protection circuit, including a first resistor, a p-type field effect transistor, a capacitance device and an n-type field effect transistor. The first resistor has a first terminal coupled to a first rail and a second terminal coupled to a first node. The p-type field effect transistor has a source coupled to the first rail, a gate coupled to the first node and a drain coupled to a second node. The capacitance device has a first terminal coupled to a second rail or the second node and a second terminal coupled to the first node. The n-type field effect transistor has a source coupled to the second rail, a gate coupled to the second node and a drain coupled to the first node.