Methods and systems are disclosed for reducing signal interference between Bluetooth (BT) and WLAN (e.g. WiFi) communications in an information handling system. The WLAN receiver has configurable front-end filter circuitry. Based upon information concerning the BT frequency region for current BT communications, the WLAN receiver can adjust or set its configurable front-end filter circuitry to filter out the BT communications. As the BT communications hop from frequency to frequency, the WLAN receiver can continue to adjust its configurable front-end filter circuitry accordingly. Example implementations for the configurable front-end filter circuitry include bandpass filters and selectable low pass and high pass filters. These filters are selected and/or tuned such that BT frequency regions are filtered from the WLAN input signal before further WLAN signal processing is conducted, thereby improving the performance of simultaneous BT and WLAN communications.