A server system is configured to provide an e-mail based interface for executing management operations on a virtualized infrastructure which includes a plurality of virtual machines (VMs), underlying host computers, clusters, and/or data centers. Such an interface may be provided in a virtualized infrastructure to enable a system administrator to execute administrative operations remotely from a mobile device without requiring custom installation of an application on the mobile device or a secure connection to the server system. The server system receives e-mails at a pre-determined e-mail address, authenticates the sender of the e-mail, and extracts and executes commands from the e-mail. A number of techniques for validating the e-mail containing server commands may also be provided.