An anti-microbial sponge device provides an ergonomic gripping surface while also resisting the accumulation of microbial agents thereon. The device includes a gripping surface having a top side, a bottom side, and a perimeter wall extending between the top side and the bottom side. The perimeter wall comprises a front side opposite a back side, and a pair of opposed lateral sides extending between the front side and the back side. Each of the lateral sides is concavely arcuate. Each of the top side, the front side, and the back side is convexly arcuate. A sponge surface is coupled to the gripping surface. The sponge surface extends outwardly from the bottom side of the gripping surface. The sponge surface comprises a porous material. The sponge surface is non-absorbent wherein the sponge surface is configured to resist an accumulation of microbial agents thereon.