Invention Grant
US09050249B2 Oral pharmaceutical compositions in timed-release particle form and fast-disintegrating tablets containing this composition
有权
定时释放颗粒形式的口服药物组合物和含有该组合物的快速崩解片剂
- Patent Title: Oral pharmaceutical compositions in timed-release particle form and fast-disintegrating tablets containing this composition
- Patent Title (中): 定时释放颗粒形式的口服药物组合物和含有该组合物的快速崩解片剂
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Application No.: US11119460Application Date: 2005-04-28
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Publication No.: US09050249B2Publication Date: 2015-06-09
- Inventor: Takayuki Yoshida , Hiroaki Tasaki , Masataka Katsuma , Atsushi Maeda
- Applicant: Takayuki Yoshida , Hiroaki Tasaki , Masataka Katsuma , Atsushi Maeda
- Applicant Address: JP Tokyo
- Assignee: ASTELLAS PHARMA INC.
- Current Assignee: ASTELLAS PHARMA INC.
- Current Assignee Address: JP Tokyo
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: A61K9/16
- IPC: A61K9/16 ; A61K31/135 ; A61K47/02 ; A61K47/04 ; A61K47/10 ; A61K47/12 ; A61K47/18 ; A61K47/24 ; A61K47/26 ; A61K47/32 ; A61K47/34 ; A61K47/36 ; A61K47/38 ; A61K47/40 ; A61K47/42 ; A61K9/00 ; A61K9/20 ; A61K9/50
Abstract:
The present invention relates to an oral pharmaceutical composition in particle form, which comprises particles that contain a drug at the core of the pharmaceutical composition in particle form; a middle layer that contains two types of water-soluble components, an insolubilizer and an insolubilizing substance; and an outer layer for controlling water penetration that contains a water-insoluble substance. The present invention makes it possible to provide a pharmaceutical composition in particle form for oral use with which initial drug release is suppressed, the drug is quickly released thereafter, and lag time can be controlled as needed, and fast-disintegrating tablets containing this composition.
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