Invention Grant
US09050269B2 Protection of virus particles from phagocytosis by expression of CD47
有权
通过CD47的表达保护病毒颗粒免于吞噬作用
- Patent Title: Protection of virus particles from phagocytosis by expression of CD47
- Patent Title (中): 通过CD47的表达保护病毒颗粒免于吞噬作用
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Application No.: US12721287Application Date: 2010-03-10
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Publication No.: US09050269B2Publication Date: 2015-06-09
- Inventor: Dennis E. Discher , Richard Kuo-An Tsai
- Applicant: Dennis E. Discher , Richard Kuo-An Tsai
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Saul Ewing, LLP
- Agent Kathryn Doyle
- Main IPC: A61K9/51
- IPC: A61K9/51 ; C07K14/705 ; A61K39/12 ; A61K47/48 ; C12N7/00 ; A61K48/00 ; A61K39/00
Abstract:
The present invention relates to a viral particle. The viral particle has a radius of less than about 1 μm, and at least one peptide comprising at least a biologically active portion of CD47. The present invention also includes a method of increasing the life of a particle in vivo in a mammal. The method includes the steps of expressing at least one peptide comprising at least a biologically active portion of CD47 in a viral particle, and administering the viral particle having CD47 expressed to a mammal, wherein the administered viral particle has a longer half life in the mammal than an otherwise identical viral particle that does not have CD47 expressed thereon.
Public/Granted literature
- US20100316570A1 Protection of Virus from Immune Cell Uptake Public/Granted day:2010-12-16
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