Invention Grant
- Patent Title: Therapeutic antisense oligonucleotide compositions for the treatment of inflammatory bowel disease
- Patent Title (中): 用于治疗炎症性肠病的治疗性反义寡核苷酸组合物
-
Application No.: US13569104Application Date: 2012-08-07
-
Publication No.: US09050354B2Publication Date: 2015-06-09
- Inventor: Mark K. Wedel
- Applicant: Mark K. Wedel
- Applicant Address: GB Essex
- Assignee: Atlantic Pharmaceuticals (Holdings) Limited
- Current Assignee: Atlantic Pharmaceuticals (Holdings) Limited
- Current Assignee Address: GB Essex
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02 ; C07H21/04 ; A61K31/7088 ; A61K31/711 ; C12N15/113 ; C12Q1/68 ; A61K31/7105
Abstract:
Disclosed herein is a method for the sustained amelioration and/or treatment of ulcerative colitis comprising rectal administration of a compound comprising an antisense oligonucleotide having the sequence 5′-GCCCAAGCTGGCATCCGTCA-3′, ISIS 2302. The method results in a decrease in the indications of ulcerative colitis for an extended period (greater than 90 days) after the conclusion of the administration of the composition. The composition is well tolerated and systemic exposure is minimal.
Public/Granted literature
- US20130090368A1 THERAPEUTIC ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE Public/Granted day:2013-04-11
Information query
