Invention Grant
- Patent Title: Bi-specific digoxigenin binding antibodies
- Patent Title (中): 双特异性地高辛结合抗体
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Application No.: US13382505Application Date: 2010-06-30
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Publication No.: US09050375B2Publication Date: 2015-06-09
- Inventor: Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
- Applicant: Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche, Inc.
- Current Assignee: Hoffmann-La Roche, Inc.
- Current Assignee Address: US NJ Little Falls
- Agent Janet M. Martineau
- Priority: EP09164612 20090706
- International Application: PCT/EP2010/059243 WO 20100630
- International Announcement: WO2011/003780 WO 20110113
- Main IPC: C07K16/46
- IPC: C07K16/46 ; A61K49/00 ; A61K49/16 ; A61K47/48 ; A61K31/704 ; A61K39/395 ; B82Y5/00 ; C07K16/16 ; C07K16/28 ; C07K16/32 ; C07K16/44 ; C12N15/11 ; C12N15/113 ; A61K39/00
Abstract:
This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
Public/Granted literature
- US20120282280A1 BI-SPECIFIC DIGOXIGENIN BINDING ANTIBODIES Public/Granted day:2012-11-08
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