A clamping mechanism for surface blasting of workpieces includes a base seat, a following assembly and a linking assembly. The following assembly is mounted on the base seat. The linking assembly is mounted on the following assembly, in which the linking assembly includes a lower rod, an upper rod, at least two linking bars and a plurality of loading members; the lower rod, the upper rod and the at least two linking rods cooperatively forming a four-bar linkage mechanism. The plurality of loading members are fixed to the at least two linking bars, such that the plurality of loading members are capable of turning over workpieces for surface blasting without requiring any positional readjustment of the workpieces by hand.