Invention Grant
- Patent Title: 1-substituted indazole derivative
- Patent Title (中): 1-取代的吲唑衍生物
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Application No.: US14137904Application Date: 2013-12-20
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Publication No.: US09051295B2Publication Date: 2015-06-09
- Inventor: Hiroki Yamaguchi , Shinya Usui , Yoko Nakai
- Applicant: Dainippon Sumitomo Pharma Co., Ltd.
- Applicant Address: JP Osaka
- Assignee: Sumitomo Dainippon Pharma Co., Ltd.
- Current Assignee: Sumitomo Dainippon Pharma Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Fish & Richardson P.C.
- Priority: JP2012-089057 20120410
- Main IPC: C07D231/56
- IPC: C07D231/56 ; C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D405/12 ; C07D471/04 ; C12N15/00

Abstract:
A medicament for treating diseases associated with cholinergic properties in the central nervous system (CNS) and/or peripheral nervous system (PNS), diseases associated with smooth muscle contraction, endocrine disorders, neurodegenerative disorders and the like, which comprises a compound of Formula (I): wherein A is CR1E or a nitrogen atom, X—Y—Z is N—CO—NR3AR3B and the like, R1A to R1E are each independently a hydrogen atom and the like, R2A to R2D are each independently a hydrogen atom and the like, R3A and R3B are each independently an optionally-substituted C3-10 cycloalkyl and the like, and n is 1 or 2 or a pharmaceutically acceptable salt thereof, which exhibits potent modulatory-effects on the activity of α7 nicotinic acetylcholine receptor (α7 nAChR).
Public/Granted literature
- US20140121244A1 NOVEL 1-SUBSTITUTED INDAZOLE DERIVATIVE Public/Granted day:2014-05-01
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