Invention Grant
US09051303B2 Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxol-5-YL)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan-2-YL)-1H-indol-5-YL)-cyclopropanecarboxamide
有权
（R）-1（2,2-二氟苯并[D] [1,3]二氧杂环戊烯-5-YL）-N-（1-（2,3-二羟基丙基-6-氟-2-（1- 羟基-2-甲基丙-2-炔基）-1H-吲哚-5-YL） - 环丙烷甲酰胺
![Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxol-5-YL)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan-2-YL)-1H-indol-5-YL)-cyclopropanecarboxamide](/docs/US/2015-06-09/US09051303B2/abs.jpg.600x600.jpg)
- Patent Title: Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxol-5-YL)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan-2-YL)-1H-indol-5-YL)-cyclopropanecarboxamide
- Patent Title (中): （R）-1（2,2-二氟苯并[D] [1,3]二氧杂环戊烯-5-YL）-N-（1-（2,3-二羟基丙基-6-氟-2-（1- 羟基-2-甲基丙-2-炔基）-1H-吲哚-5-YL） - 环丙烷甲酰胺
-
Application No.: US14318131Application Date: 2014-06-27
-
Publication No.: US09051303B2Publication Date: 2015-06-09
- Inventor: Ali Keshavarz-Shokri , Beili Zhang , Tim Edward Alcacio , Elaine Chungmin Lee , Yuegang Zhang , Mariusz Krawiec
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: VERTEX PHARMACEUTICALS INCORPORATED
- Current Assignee: VERTEX PHARMACEUTICALS INCORPORATED
- Current Assignee Address: US MA Boston
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Heidi M. Berven; Jonathan P. O'Brien
- Main IPC: A61K31/36
- IPC: A61K31/36 ; C07D405/12 ; A61K31/404 ; A61K45/06 ; A61K31/47
![Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxol-5-YL)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan-2-YL)-1H-indol-5-YL)-cyclopropanecarboxamide](/abs-image/US/2015/06/09/US09051303B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
Public/Granted literature
Information query
