Invention Grant
US09051331B2 Substituted dihydro benzocycloalkyloxymethyl oxazolopyrimidinones, preparation and use thereof
有权
取代的二氢苯并环烷氧基甲基恶唑啉嘧啶酮,其制备和应用
- Patent Title: Substituted dihydro benzocycloalkyloxymethyl oxazolopyrimidinones, preparation and use thereof
- Patent Title (中): 取代的二氢苯并环烷氧基甲基恶唑啉嘧啶酮,其制备和应用
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Application No.: US13410723Application Date: 2012-03-02
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Publication No.: US09051331B2Publication Date: 2015-06-09
- Inventor: Rosy Sher , Raymond Walter Kosley, Jr.
- Applicant: Rosy Sher , Raymond Walter Kosley, Jr.
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Priority: FR1055806 20100716
- Main IPC: C07D491/048
- IPC: C07D491/048 ; C07D498/04 ; A61K31/519 ; A61K31/522

Abstract:
The present invention relates to a series of substituted dihydro benzocycloalkyl-oxymethyl oxazolopyrimidinones of formula (I): Wherein n, R1, R2, R3, R4, R5 and R6 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, cognition deficit disorders, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.
Public/Granted literature
- US20120184566A1 SUBSTITUTED DIHYDRO BENZOCYCLOALKYLOXYMETHYL OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF Public/Granted day:2012-07-19
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