Invention Grant
- Patent Title: 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
- Patent Title (中): 6,7-二氢咪唑并[2,1-b] [1,3]恶嗪类杀菌剂
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Application No.: US14111262Application Date: 2012-04-13
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Publication No.: US09051333B2Publication Date: 2015-06-09
- Inventor: Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
- Applicant: Yoshikazu Kawano , Yoshikazu Haraguchi , Hirofumi Sasaki , Yukitaka Uematsu , Hidetsugu Tsubouchi , Hiromi Yata , Hiroshi Shimizu , Kazuho Kohashi , Motohiro Itotani , Kuninori Tai , Isao Takemura , Mikayo Hayashi , Hiroyuki Hashizume , Miki Matsuba , Izuru Nakamura , Xiuhao Chen , Makoto Matsumoto
- Applicant Address: JP Tokyo
- Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
- Current Assignee: OTSUKA PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- International Application: PCT/JP2012/060645 WO 20120413
- International Announcement: WO2012/141338 WO 20121018
- Main IPC: C07D498/04
- IPC: C07D498/04 ; A61K31/5383
![6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides](/abs-image/US/2015/06/09/US09051333B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.
Public/Granted literature
- US20140031342A1 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES Public/Granted day:2014-01-30
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