Invention Grant
- Patent Title: Optimized Fc variants
- Patent Title (中): 优化的Fc变体
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Application No.: US13764693Application Date: 2013-02-11
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Publication No.: US09051373B2Publication Date: 2015-06-09
- Inventor: Gregory Alan Lazar , Wei Dang , John Desjarlais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
- Applicant: Xencor, Inc.
- Applicant Address: US CA Monrovia
- Assignee: Xencor, Inc.
- Current Assignee: Xencor, Inc.
- Current Assignee Address: US CA Monrovia
- Agency: Morgan, Lewis & Bockius, LLP
- Agent Robin M. Silva; Christina A. MacDougall
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08 ; C07K16/28 ; C07K16/32 ; C07K1/00
Abstract:
The present invention relates to a variant Fc region comprising an amino acid substitution at position 238 of the Fc region as compared to a human parent Fc region, wherein the variant Fc region comprises a 238D substitution, wherein the variant Fc region binds FcγRIIb with increased binding affinity compared to a human parent Fc region.
Public/Granted literature
- US20130209457A1 Optimized Fc Variants Public/Granted day:2013-08-15
Information query
