Invention Grant
- Patent Title: Methods for enhancing hematopoietic stem/progenitor cell engraftment
- Patent Title (中): 增强造血干/祖细胞移植的方法
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Application No.: US13147710Application Date: 2010-02-03
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Publication No.: US09051548B2Publication Date: 2015-06-09
- Inventor: Leonard I. Zon , Pulin Li
- Applicant: Leonard I. Zon , Pulin Li
- Applicant Address: US MA Boston
- Assignee: Children's Medical Center Corporation
- Current Assignee: Children's Medical Center Corporation
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- International Application: PCT/US2010/022998 WO 20100203
- International Announcement: WO2010/091052 WO 20100812
- Main IPC: A01N63/00
- IPC: A01N63/00 ; C12N5/0789 ; A61K31/221 ; A61K31/255 ; A61K31/19 ; A61K31/095 ; A61K31/21 ; A61K35/12
Abstract:
Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.
Public/Granted literature
- US20110293582A1 METHODS FOR ENHANCING HEMATOPOIETIC STEM/PROGENITOR CELL ENGRAFTMENT Public/Granted day:2011-12-01
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