Invention Grant
US09051551B2 Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors
有权
增加对酪氨酸激酶抑制剂敏感性的方法和组合物
- Patent Title: Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors
- Patent Title (中): 增加对酪氨酸激酶抑制剂敏感性的方法和组合物
-
Application No.: US13511181Application Date: 2010-11-24
-
Publication No.: US09051551B2Publication Date: 2015-06-09
- Inventor: Peter Jeffery Leedman , Keith Michael Giles , Felicity Caris Kalinowski
- Applicant: Peter Jeffery Leedman , Keith Michael Giles , Felicity Caris Kalinowski
- Applicant Address: AU Nedlands, Western Australia
- Assignee: The University of Western Australia
- Current Assignee: The University of Western Australia
- Current Assignee Address: AU Nedlands, Western Australia
- Agency: Casimir Jones, S.C.
- Priority: AU2009905758 20091124
- International Application: PCT/AU2010/001578 WO 20101124
- International Announcement: WO2011/063456 WO 20110603
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12Q1/68 ; C12N5/09 ; A61K31/7105 ; A61K31/7088 ; C12N15/113
Abstract:
The present invention relates to a method for sensitizing a disease cell expressing the epidermal growth factor receptor (EGFR) to a tyrosine kinase inhibitor selective or specific for EGFR and/or its signalling pathway, the method comprising contacting the cell with a miR-7 miRNA, a precursor or variant thereof, or a miRNA comprising a seed region comprising the sequence GGAAGA.
Public/Granted literature
- US20130116299A1 METHODS AND COMPOSITIONS FOR INCREASING SENSITIVITY TO TYROSINE KINASE INHIBITORS Public/Granted day:2013-05-09
Information query
IPC分类:
