Invention Grant
- Patent Title: Purification of iduronate-2-sulfatase
- Patent Title (中): 异丙肾上腺素-2-硫酸酯酶的纯化
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Application No.: US13829706Application Date: 2013-03-14
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Publication No.: US09051556B2Publication Date: 2015-06-09
- Inventor: Dave Nichols
- Applicant: Shire Human Genetic Therapies, Inc.
- Applicant Address: US MA Lexington
- Assignee: Shire Human Genetic Therapies, Inc.
- Current Assignee: Shire Human Genetic Therapies, Inc.
- Current Assignee Address: US MA Lexington
- Agency: Choate, Hall & Stewart LLP
- Agent Fangli Chen; Robert N. Sahr
- Main IPC: C12N9/00
- IPC: C12N9/00 ; C12N9/16 ; C12N1/20 ; C12N15/00 ; C07H21/04
Abstract:
The present invention provides, among other things, improved methods for purifying I2S protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant I2S protein can be purified from unprocessed biological materials, such as, I2S-containing cell culture medium, using a process involving as few as four chromatography columns.
Public/Granted literature
- US20140004096A1 PURIFICATION OF IDURONATE-2-SULFATASE Public/Granted day:2014-01-02
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