An oil-mist-free and high-speed electric spindle of the present invention includes a shell, a stator and a rotator. Using a bearing provided on a bearing providing position of the shell, the stator and the rotor are separated by a gap and freely rotatably supported on the shell. A labyrinth sealing structure, which covers the bearing providing position, is provided on an outside of the bearing providing position. The labyrinth sealing structure has a channel which opens to an atmosphere. And a through-hole is provided on the shell, wherein one end of the through-hole opens to the shelter, and the other end of the through-hole is connected with the channel of the labyrinth sealing structure. And the bearing providing position is filled with a lubricating grease which is a total synthesis grease of polyurea that is mainly composed of a base oil and contains a nanometer anti-wear additive.