Systems and methods for clinical event processing with situational awareness to dynamically facilitate a clinician's workflow are provided. An example clinical event processing and situational awareness system includes a clinical event processor including a clinical event processing engine and a routing engine to receive information regarding a clinical event from an event source and to process the information regarding the clinical event to determine a clinical situation based on the clinical event. The system also includes an event handler to enrich the processed information regarding the clinical event by adding a clinical context to the processed information from a data source. The system further includes a dispatcher to notify a user and launch an anticipated application for the user to facilitate a situational aware clinical workflow based on the enriched, processed information regarding the clinical event.