A method and system is provided for combining information from a plurality of source images to form a fused image. The fused image is generated by the combination of the source images based on both local features and global features computed from the source images. Local features are computed for local regions in each source image. For each source image, the computed local features are further processed to form a local weight matrix. Global features are computed for the source images. For each source image, the computed global features are further processed to form a global weight vector. For each source image, its corresponding local weight matrix and its corresponding global weight vector are combined to form a final weight matrix. The source images are then weighted by the final weight matrices to generate the fused image.