An electronic musical instrument whose operation is similar to a harmonica, and which can be played easily by anyone familiar with a harmonica. The instrument measures positive or negative pressure at the mouthpiece, with a MEMS (Micro-electro-mechanical system) pressure sensor, which produces an electronic signal, which is then converted to pre-sampled sounds of a variety of instruments via an on-board synthesizer, and is capable of sending MIDI (Musical Instrument Digital Interface) signals to control other electronic musical instruments or devices.