Electronic devices may include image sensors having image pixel arrays with image pixels arranged in pixel rows and pixel columns. Each pixel column may be coupled to a column line having column readout circuitry. The column readout circuitry on each column line may include signal processing circuitry and a latch circuit. The latch circuit on each column line may be used to selectively enable and disable the signal processing circuitry on that column line. Each latch circuit may be coupled to first and second signal lines for globally enabling and disabling the signal processing circuitry on all of the column lines. Each latch circuit may be coupled to column decoder circuitry. The column decoder circuitry may provide a column-select signal to latch circuits on a chosen subset of column lines that enables the signal processing circuitry on those column lines by setting those latch circuits.