The present invention discloses a control device for a touch panel that comprises a plurality of X-directional sensing lines and Y-directional sensing lines. The X-directional sensing lines and Y-directional sensing lines are arranged in an interlaced manner. The control device comprises a clock generation circuit, a selection module, a driving signal generation circuit, a differential detection module, and a digital-to-analog conversion module. The selection module selects a first sensing line and a second sensing line from the X-directional sensing lines or Y-directional sensing lines. The driving signal generation circuit generates first and second driving signals to the first and second sensing lines, respectively. The digital to analog conversion module selectively outputs a first voltage to the first sensing line or outputs a second voltage to the second sensing line. The operation frequency of the touch panel can be increased using the control device of the present invention.