A communication system may include a plurality of near-field communication (NFC) sensors each associated with a respective location, and a mobile wireless communications device(s) switchable among a plurality of different power consumption modes. The mobile wireless communications device(s) may include a portable housing, an NFC circuit carried by the housing and configured to establish NFC communications with at least one of the NFC sensors when in proximity therewith, and a plurality of different wireless communications circuits carried by the housing. The mobile wireless communications device(s) may further include a controller carried by the housing and coupled to the NFC circuit and the different wireless communications circuits which may be configured to switch to a given power consumption mode based upon the at least one NFC sensor. In particular, some of the different power consumption modes may be associated with selectively powering respective ones of the wireless communications circuits.