Invention Grant
US09072707B2 Use of C-terminal domain of IGFBP-5 comprising heparin-binding domain as an angiogenesis inhibitor
有权
使用包含肝素结合结构域的IGFBP-5的C-末端结构域作为血管生成抑制剂
- Patent Title: Use of C-terminal domain of IGFBP-5 comprising heparin-binding domain as an angiogenesis inhibitor
- Patent Title (中): 使用包含肝素结合结构域的IGFBP-5的C-末端结构域作为血管生成抑制剂
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Application No.: US14049621Application Date: 2013-10-09
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Publication No.: US09072707B2Publication Date: 2015-07-07
- Inventor: Jae Ryoung Hwang
- Applicant: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
- Applicant Address: KR Suwon-si
- Assignee: Research & Business Foundation Sungkyunkwan University
- Current Assignee: Research & Business Foundation Sungkyunkwan University
- Current Assignee Address: KR Suwon-si
- Agency: NSIP Law
- Priority: KR10-2012-0112111 20121009
- Main IPC: A61K38/10
- IPC: A61K38/10 ; A61K38/18
Abstract:
The present invention relates to a pharmaceutical composition for inhibiting angiogenesis comprising an isolated peptide comprising the heparin-binding domain of insulin-like growth factor-binding protein-5 (IGFBP-5), a method for inhibiting angiogenesis using the peptide, a pharmaceutical composition for the prevention or treatment of cancer comprising the peptide, a method for treating cancer using the peptide, a novel angiogenesis-inhibiting peptide derived from heparin-binding domain of IGFBP-5, a polynucleotide encoding the peptide, an expression vector comprising the polynucleotide and a transformant comprising the vector.
Public/Granted literature
- US20140100160A1 NOVEL USE OF C-TERMINAL DOMAIN OF IGFBP-5 COMPRISING HEPARIN-BINDING DOMAIN AS AN ANGIOGENESIS INHIBITOR Public/Granted day:2014-04-10
Information query
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