Invention Grant
US09072723B2 Medical device with coating that promotes endothelial cell adherence
有权
具有促进内皮细胞粘附的涂层的医疗装置
- Patent Title: Medical device with coating that promotes endothelial cell adherence
- Patent Title (中): 具有促进内皮细胞粘附的涂层的医疗装置
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Application No.: US13589907Application Date: 2012-08-20
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Publication No.: US09072723B2Publication Date: 2015-07-07
- Inventor: Michael John Bradley Kutryk , Robert J. Cottone, Jr. , Stephen M. Rowland
- Applicant: Michael John Bradley Kutryk , Robert J. Cottone, Jr. , Stephen M. Rowland
- Applicant Address: US FL Fort Lauderdale
- Assignee: ORBUS MEDICAL TECHNOLOGY INC
- Current Assignee: ORBUS MEDICAL TECHNOLOGY INC
- Current Assignee Address: US FL Fort Lauderdale
- Agency: Ascenda Law Group PC
- Main IPC: A61F2/06
- IPC: A61F2/06 ; A61K38/39 ; A61L27/08 ; A61L27/22 ; A61L27/30 ; A61L27/44 ; A61L27/54 ; A61L29/10 ; A61L29/12 ; A61L29/16 ; A61L31/04 ; A61L31/08 ; A61L31/12 ; A61L31/16 ; C12N5/071 ; A61K38/36 ; A61K39/395 ; C07K16/28 ; B82Y30/00

Abstract:
The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.
Public/Granted literature
- US20130035755A1 MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE Public/Granted day:2013-02-07
Information query
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