Invention Grant
- Patent Title: Cyclic amide derivative
- Patent Title (中): 环状酰胺衍生物
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Application No.: US14114017Application Date: 2012-04-11
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Publication No.: US09072758B2Publication Date: 2015-07-07
- Inventor: Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
- Applicant: Akihiro Okano , Munetaka Ohkouchi , Muneyoshi Makabe
- Applicant Address: JP Tokyo
- Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.
- Current Assignee: MOCHIDA PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2011-102535 20110428; JP2011-185340 20110826; WOPCT/JP2011/073355 20111011; JP2012-044857 20120229
- International Application: PCT/JP2012/059915 WO 20120411
- International Announcement: WO2012/147516 WO 20121101
- Main IPC: C07D279/02
- IPC: C07D279/02 ; C07D285/10 ; C07D285/16 ; C07D417/12 ; C07D417/14 ; A61K31/69 ; A61K31/425 ; A61K31/4439 ; A61K31/54 ; A61K31/541 ; A61K31/549 ; A61K45/06 ; C07D275/03 ; C07F5/04 ; A61K9/14 ; A61K9/16 ; A61K9/20 ; A61K9/48

Abstract:
[Problem]To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogues and a prophylactic and/or therapeutic agent against diabetes, obesity, or the like.[Means of solving the problem]A compound of Formula (III): (where f is 0 to 2; g is 1 to 4; j is 0 to 3; k is 0 to 2; n is 0 to 2; p is 0 to 4; h is 0 to 3; q1 id 0 to 3; q2 is 0 or 1; r1 is 0 to 2 (with the proviso that q1+q2+r1 is 0 to 5); J1a is —CR11a—, N; J2 is —CR12aR12b—, —CR12c—; T is —CH2—, O, —S(O)i— (i is an integer of 0 to 2) or —NR7—; X is O, S, or —NR7—; ring A′″ is a benzene ring, a pyridine ring; ring B′ is a benzene ring, a pyridine ring, a pyrimidine ring; and R1 to R14 are specific groups), a salt of the compound, or a solvate of the salt or the compound.
Public/Granted literature
- US20140057871A1 CYCLIC AMIDE DERIVATIVE Public/Granted day:2014-02-27
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